Relationship between Thyroid Function and Lipid Profile In Thyroid Disorder

Abstract

Thyroid disease, one of the major health hazards in Bangladesh, is mainly seen in the Northern part, along the belt of the River Brahmaputra and the Jamuna. Thyroid disorders are the second endocrine problem, next to Diabetes Mellitus (DM) in Bangladesh, with no age barrier, mostly prevalent with manifestations among the middle aged people and more among females. Thyroid hormones influence all major metabolic pathways with specific regard to lipid metabolism affecting synthesis, mobilization and degradation of lipids. Dyslipidemia, a disorder of lipoprotein metabolism may be manifested either by elevation of total cholesterol, Low Density Lipoprotein Cholesterol, (LDL-C) triglyceride or a decrease in High Density Lipoprotein Cholesterol (HDL-C) in the blood. It is a major risk factor for atherosclerotic cardiovascular diseases, leading to Coronary Heart Disease (CHD) that is Ischemic Heart Disease (!HD) in particular. In the present study thyroid function and lipid profile have been investigated in a population that is the patients with thyroid disorder which is the representative of peoples living in hyper endemic iodine deficient zone in the Northern part of Bangladesh.